Recently, a systematic review and meta-analysis paper on the use of naked plasmid encoding recombinant human hepatocyte growth factor for the treatment of chronic ischemic diseases has been published. European Journal of Vascular & Endovascular Surgery The paper was published in [journal name] (impact factor: 5.7). The co-first authors of the paper are Dr. Xi Xiao and Dr. Peng Wang from the Department of Vascular Surgery at Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, and the corresponding author is Professor Changwei Liu.

The study systematically searched databases including Medline, Embase, the Cochrane Database of Systematic Reviews, and ClinicalTrials, and included 7 randomized controlled trials (totaling 655 participants) evaluating the efficacy of HGF plasmids in patients with CLTI. A systematic review and meta-analysis were conducted. The results indicated that, based on low-certainty evidence, patients receiving HGF treatment had a significantly higher rate of complete ulcer healing (RR 1.99, 95% CI 1.30–3.04; P = 0.015) compared to those receiving placebo. During a 3-month follow-up period, patients treated with HGF showed significantly lower Visual Analog Scale (VAS) scores—related to pain severity—than the placebo group (MD −1.56, 95% CI −2.12 to −1.00; P < 0.001). The benefits in terms of both complete ulcer healing rate and improvement in 3-month VAS scores for pain severity persisted over time.

The author believes that HGF plasmid therapy has the potential to promote ulcer healing and reduce pain in patients with CLTI, and these benefits persist over time.

        Meta-analysis, Also known as a meta-analysis, this is a commonly used statistical method in medicine that combines and summarizes the results of multiple studies to draw more statistically significant conclusions. By collecting and integrating data from several independent studies, it evaluates the effectiveness, safety, or other characteristics of a particular intervention or treatment.

Original link:

https://www.ejves.com/article/S1078-5884(24)00620-8/abstract

[1] Di X, Wang P, Li F, Han W, Ni L, Liu C-W, Recombinant Human Hepatocyte Growth Factor Plasmids for Treating Patients with Chronic Limb Threatening Ischaemia: A Systematic Review and Meta-analysis, European Journal of Vascular & Endovascular Surgery (2024), doi: https://doi.org/10.1016/j.ejvs.2024.07.016.